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Nebulisers
Another product in the class of inhaled products are passive nebuliser, which continuously generate an inhalable vapour. This is achieved for example by means of ultrasound. In contrast to the afore mentioned application devices, where the active ingredient is inhaled in the course of one inhalation, in passive nebulizers the required dose is generated over several minutes and may be inhaled during a cycle of several inhalations. Therefore, the determination of the nebulized dose and its subsequent uptake, is simulated by an "artificial lung" and key to evaluate the quality of this drug-device combination.
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Metered dose inhalers (pMDI)
Dry powder inhalers (DPI)
Nasal sprays